Amy Schumer, 45, posts unfiltered bikini photos and credits Mounjaro for weight-loss shift
NEW YORK, Aug. 3. Amy Schumer, 45, posted a series of unfiltered bikini photographs on Instagram over the weekend, drawing praise from fans and fellow entertainers as she credited a tirzepatide regimen, sold under the brand name Mounjaro, and hormone therapy for changes in her body. The comedian posed in a colorful two-piece by the water, captioning the post "I never knew there would be days like this" and adding "No filter as per ushe." Actress Kate Walsh commented: "So beautiful, Amy. Happy and thriving."
Key takeaways
- Amy Schumer, 45, posted unfiltered, no-filter bikini photos on Instagram over the weekend, crediting the tirzepatide drug Mounjaro and hormone therapy for changes in her body.
- Schumer previously tried Wegovy, which made her ill immediately, and Ozempic, which left her bedridden, vomiting, and unable to lift her head, though she lost 30 pounds before stopping.
- She attributed her severe medication reactions to a gene variant called GDF15, which she said also caused nausea during pregnancy.
- Schumer's doctors placed her on estrogen and progesterone after diagnosing perimenopause, and her symptoms resolved after starting the hormones.
- She has previously disclosed a Cushing syndrome diagnosis in February 2024, endometriosis, and a 2021 hysterectomy.
NEW YORK, Aug. 3. Amy Schumer, 45, posted a series of unfiltered bikini photographs on Instagram over the weekend, drawing praise from fans and fellow entertainers as she credited a tirzepatide regimen, sold under the brand name Mounjaro, and hormone therapy for changes in her body. The comedian posed in a colorful two-piece by the water, captioning the post "I never knew there would be days like this" and adding "No filter as per ushe." Actress Kate Walsh commented: "So beautiful, Amy. Happy and thriving."
From Wegovy to Ozempic to Mounjaro
Schumer has documented a years-long search for a weight-loss medication she could tolerate. She tried Wegovy first and became ill immediately. Then, as she described on "The Howard Stern Show," she tried Ozempic roughly three years before a March 2025 Instagram video she recorded while driving. She said Ozempic left her bedridden, vomiting, and unable to lift her head. She reported losing 30 pounds on the drug before stopping. She attributed her reaction to a gene variant, GDF15, which she said made her similarly prone to nausea during pregnancy.
Mounjaro (tirzepatide) is primarily indicated for type 2 diabetes. Schumer said she found it through a telehealth appointment with MidiHealth, describing the service as inexpensive. She wanted to evaluate it herself, she said, before recommending it to friends who work as nurses and teachers.
Hormone therapy and prior diagnoses
Alongside tirzepatide, Schumer said her physicians placed her on estrogen and progesterone after identifying that she was in perimenopause. Her perimenopause symptoms resolved after starting the hormones, she reported.
In February 2024, she disclosed a diagnosis of Cushing syndrome, which she said led doctors to find its underlying cause. She has spoken publicly for several years about living with endometriosis and about a hysterectomy she underwent in 2021. She is the mother of son Gene, shared with ex-husband Chris Fischer.
Earlier photographs and audience response
In October, Schumer appeared at a Paul McCartney concert in Las Vegas in a black dress alongside two friends. Comedian Anjelah Johnson and actress Isla Fisher both commented on photographs from that night, Fisher singling out Schumer's legs. The weekend's bikini post drew similar attention from followers. "Gorgeous," one wrote.